How to write a protocol for a systematic review

Outcomes Study design The review question can be framed in terms of the population, intervention scomparator s and outcomes of the studies that will be included in the review.

How to write a protocol for a systematic review

A young researcher's guide to a systematic review Series: Part04 - Types of articles: A guide for young researchers Key takeaways: A systematic review is a thorough and detailed review of existing literature on a particular topic, designed to address a specific question. Systematic reviews are especially important in evidence-based medicine.

A good systematic review begins with a protocol that defines the study design, objectives, and expected outcomes; follows the PRISMA guidelines, and should be registered in a recognized protocol registry.

Apr 29, A systematic review is a highly rigorous review of existing literature that addresses a clearly formulated question. The review systematically searches, identifies, selects, appraises, and synthesizes research evidence relevant to the question using methodology that is explicit, reproducible, and leads to minimum bias.

THE REVIEW PROTOCOL

Systematic reviews are regarded as the best source of research evidence. Systematic reviews are absolutely crucial in the field of evidence-based medicine, but are also highly valued in other fields.

A systematic review is more exhaustive than a literature review as it includes both published and unpublished literature, often called grey literature. Grey literature is a significant part of a systematic review and adds value to the review.

This is because grey literature is often more current than published literature and is likely to have less publication bias. Grey literature includes unpublished studies, reports, dissertations, conference papers and abstracts, governmental research, and ongoing clinical trials.

Conducting a systematic review is a complex process. This article aims to guide you on the different kinds of systematic review, the standard procedures to be followed, and the best approach to conducting and writing a systematic review.

Types of systematic reviews Qualitative: In this type of systematic review, the results of relevant studies are summarized but not statistically combined.

This type of systematic review uses statistical methods to combine the results of two or more studies. A meta-analysis uses statistical methods to integrate estimates of effect from relevant studies that are independent but similar and summarize them.

Writing a protocol Any good systematic review begins with a protocol.

how to write a protocol for a systematic review

According to the National Institutes of Health NIHa protocol serves as a road-map for your review and specifies the objectives, methods, and outcomes of primary interest of the systematic review.

The purpose of having a protocol is to promote transparency of methods. A protocol defines the search terms, inclusion and exclusion criteria, data that will be analyzed, etc. The protocol needs to be submitted to the journal along with your manuscript.

Most journals expect authors of systematic reviews to use the PRISMA statement or similar other guidelines to write their protocol. A protocol ideally includes the following: Databases to be searched and additional sources particularly for grey literature Keywords to be used in the search strategy Limits applied to the search.protocol is entitled “Systematic review to evaluate the evidence for an association between perfluorooctanoic.

acid (PFOA) or perfluorooctane sulfonate (PFOS) exposure and immunotoxicity.” These two case studies will be. conducted as guidance for . A systematic review is a highly rigorous review of existing literature that addresses a clearly formulated question.

Systematic reviews are regarded as the best source of research evidence. This article discusses the types of systematic review, systematic review protocol and its registration, and the best approach to conducting and writing a.

THE REVIEW PROTOCOL Introduction.

how to write a protocol for a systematic review

The review protocol sets out the methods to be used in the review. Decisions about the review question, inclusion criteria, search strategy, study selection, data extraction, quality assessment, data synthesis and plans for dissemination should be addressed.

Systematic reviews should set clear. Writing Your Protocol Guidance notes for registering a systematic review protocol with PROSPERO This guide outlines the registration process for PROSPERO protocols, including full descriptions of each field on the registration form.

Systematic Review Protocol & Support Template This template is primarily intended to help you plan your review in a systematic way. A copy of this completed form will be available via the intranet to help others carrying out reviews in the future and to Writing up “” Version 3, March A systematic review protocol describes in advance the rationale, hypothesis, and methods you plan to use in your review.

It serves many functions: It serves many functions: As a road map to the team when conducting the review.

A young researcher's guide to a systematic review Editage Insights